ABSTRACT
Objective The factors influencing the prognosis of laparoscopic radical resection of colorectal cancer remain controversial. This study was to investigate the effect of visceral fat area (VFA) on the prognosis of laparoscopic radical resection of colorectal cancer and provide evidence for evaluating the prognosis of patients with colorectal cancer. Methods A retrospective analysis was made on the clinical data of 218 patients undergoing laparoscopic radical resection of colorectal cancer in the Department of Gastrointestinal Surgery of Affiliated Hospital of Southwest Medical University from March 2013 to June 2014. The patients were divided into VFA-S group (VFA<100cm2, n=106) and VFA-L group (VFA≥100m2, n=112) according to the measured VFA values. The basic clinical data of the two groups were compared and the short-term and long-term prognosis of VFA were evaluated by logistic regression and Cox regression models. Results The incidence of complication and the incidence of minor complications (13.2%, 9.4%) in VFA group were significantly lower than those in control group (27.7%, 19.6%), and the difference was statistically significant (P<0.05). The overall survival rate of patients in VFA group at 1 year, 3 years, and 5 years (98.1%, 87.7%, 70.8%) was significantly greater than that of control group (93.8%, 67.9%, 58.0%), and the difference was statistically significant (P< 0.05). The disease-free survival rate (98.1%, 84.0%, 70.8%) at 1 year, 3 years, and 5 years after surgery was significantly higher in VFA group than that in control group (92.0%, 67.9%, 58.0%), and the difference was statistically significant (P <0.05). The Kaplan-Meier curve showed that the overall survival and disease-free survival (58.91 months, 57.82 months) in VFA group were significantly greater than those in control group (51.61 months, 50.60 months), and the difference was statistically significant (P<0.05). The overall survival and disease-free survival were associated with ASA classification, differentiation, TNM stage, and VFA (P<0.05). Conclusion VFA has an impact on short-term and long-term prognosis after laparoscopic radical resection of colorectal cancer. VFA≥100cm2 indicates that patients have a high possibility of postoperative complications and poor prognosis.
ABSTRACT
OBJECTIVE@#To analyze the hepatic protection of n-acetyl cysteine (NAC) on severe acute pancreatitis (SAP).@*METHODS@#SD rats were randomly divided into control group, SAP group and NAC group. SAP AHO method was adopted to establish the model, 2 h after modeling, rats in NAC group had intraperitoneal injection of NAC (200 mg/kg). Ten rats from each group were sacrificed in every 6 and 12 h at different time points respectively. Liver damage, liver function and serum amylase, AST, ALT and malondialdehyde (MDA) were determined.@*RESULTS@#Serum amylase, AST, ALT and MDA content in SAP, NAC group at each time point were significantly higher in the control group (P<0.05), serum amylase, AST, ALT and MDA content in NAC group rats were lower in the SAP group significantly (P<0.05); Microscopic examination showed that the liver injury in rats and the NAC group significantly reduced in the SAP group.@*CONCLUSIONS@#NAC provides effective protection against liver damage to SAP, protective from SAP liver injury.